Anti-Anginal Pharmacology Exam

AA1 • Question 1

Which drug formulation provides the fastest relief of acute anginal pain?

Oral isosorbide mononitrate Nitroglycerin transdermal patch Sublingual nitroglycerin Propranolol Ranolazine

AA2 • Question 2

The primary mechanism by which nitrates relieve angina is:

Decrease myocardial contractility Increase coronary artery plaque stability Reduce preload via venodilation Block calcium influx in cardiac cells Increase heart rate

AA3 • Question 3

Which drug is contraindicated in combination with nitrates?

Aspirin Metoprolol Sildenafil Atorvastatin Clopidogrel

AA4 • Question 4

Beta-blockers improve angina primarily by:

Dilating coronary arteries Reducing heart rate and contractility Increasing preload Blocking sodium channels Increasing nitric oxide production

AA5 • Question 5

Which class of drugs is most effective for vasospastic (Prinzmetal) angina?

Beta-blockers Calcium channel blockers ACE inhibitors Loop diuretics Digoxin

AA6 • Question 6

Nitrate tolerance can be minimized by:

Increasing dose gradually Using continuous infusion Providing a daily nitrate-free interval Combining with beta-blockers only Administering at bedtime only

AA7 • Question 7

Which anti-anginal reduces heart rate and AV nodal conduction?

Amlodipine Isosorbide dinitrate Verapamil Hydralazine Ranolazine

AA8 • Question 8

Ranolazine works primarily by:

Increasing nitric oxide release Blocking beta-1 receptors Reducing late sodium current in cardiac cells Blocking L-type calcium channels Increasing diuresis

AA9 • Question 9

Which anti-anginal is contraindicated in severe bradycardia?

Amlodipine Nitroglycerin Metoprolol Isosorbide mononitrate Ranolazine

AA10 • Question 10

The major hemodynamic effect of nitroglycerin is:

Afterload reduction only Preload reduction primarily Increased myocardial contractility Increased heart rate Direct coronary artery dilation only

AA11 • Question 11

Which anti-anginal drug is NOT appropriate for variant angina?

Nifedipine Diltiazem Nitroglycerin Propranolol Amlodipine

AA12 • Question 12

Headache is a common side effect of which anti-anginal drug?

Ranolazine Nitroglycerin Metoprolol Verapamil Aspirin

AA13 • Question 13

Which drug reduces myocardial oxygen demand by lowering blood pressure without significantly affecting heart rate?

Amlodipine Propranolol Metoprolol Verapamil Ivabradine

AA14 • Question 14

In chronic stable angina, which combination improves exercise tolerance?

Nitrate + beta-blocker Digoxin + ACE inhibitor Statin + aspirin Loop diuretic + nitrate Spironolactone + hydralazine

AA15 • Question 15

Which anti-anginal may prolong the QT interval?

Metoprolol Nitroglycerin Amlodipine Ranolazine Isosorbide dinitrate