Clobetasol

• Very high-potency topical glucocorticoid (Class I)

Parent class:

• Corticosteroids

Topical glucocorticoid receptor activation → decreased local cytokine production → reduced inflammation and immune cell activity.

See:

• Glucocorticoid Signaling

• Cream
• Ointment
• Foam
• Solution
• Shampoo (psoriasis)

• Severe psoriasis
• Refractory eczema
• Lichen planus
• Other severe inflammatory dermatoses

Local:

• Skin thinning
• Striae
• Telangiectasia
• Hypopigmentation

Systemic (rare, with large-area use):

• HPA axis suppression

• Class I potency (strongest topical class).
• Avoid long-term use.
• Avoid use on face or intertriginous areas.
• Limit duration (typically ≤2 weeks continuous use).