Betamethasone

• Long-acting systemic glucocorticoid
• High-potency corticosteroid
• No mineralocorticoid activity

Parent class:

• Corticosteroids

Binds intracellular glucocorticoid receptors → alters gene transcription → strong suppression of inflammatory cytokines and eicosanoid production.

See:

• Glucocorticoid Signaling Pathway

• Very high glucocorticoid potency
• Long duration (36–72 hours)
• No sodium-retaining activity
• Strong HPA suppression with prolonged use

Chemically similar to Dexamethasone.

• IM injection
• Topical (various potency preparations)

Systemic:

• Fetal lung maturation (antenatal therapy)
• Severe inflammatory conditions

Topical:

• Dermatitis
• Psoriasis

Systemic:

• Hyperglycemia
• Mood changes
• Immunosuppression
• HPA suppression

Topical:

• Skin atrophy
• Telangiectasia
• Striae

• Commonly used in obstetrics for fetal lung maturation.
• Long-acting and highly potent.
• No mineralocorticoid activity.
• Strong adrenal suppression risk if used chronically.