====== Rheumatology & Immunosuppressants ======**Inflammatory & autoimmune disease pharmacology**  <WRAP center round box 85%>This section organizes therapy by **immune pathway -> drug class -> clinical use**.Start with foundations, then move through drug classes and disease-specific pathways.</WRAP>----===== Quick Start =====  * **Foundations:** [[basics:start|Immunology Physiology]] · [[allergy:start|Histamine / Hypersensitivity]] · [[eicosanoids:start|Eicosanoids (NSAIDs & Leukotrienes)]]  * **Core classes:** [[rheum:dmards:start|Conventional DMARDs]] · [[rheum:biologics:start|Biologic DMARDs]] · [[rheum:jak:start|JAK / Targeted Therapies]] · [[rheum:glucocorticoids:start|Glucocorticoids]]  * **Key diseases:** [[rheum:ra:start|Rheumatoid Arthritis]] · [[rheum:psa:start|Psoriatic Arthritis]] · [[rheum:as:start|Ankylosing Spondylitis]] · [[rheum:sle:start|Systemic Lupus (SLE)]] · [[rheum:gout:start|Gout]]----===== Drug Classes ========= Conventional DMARDs ====  * [[rheum:dmards:methotrexate|Methotrexate]]  * [[rheum:dmards:hydroxychloroquine|Hydroxychloroquine]]  * [[rheum:dmards:sulfasalazine|Sulfasalazine]]  * [[rheum:dmards:leflunomide|Leflunomide]]  * [[rheum:dmards:azathioprine|Azathioprine]]  * [[rheum:dmards:mycophenolate|Mycophenolate]]==== Biologic DMARDs ====  * [[rheum:biologics:tnf|TNF inhibitors]] (adalimumab, etanercept, infliximab, etc.)  * [[rheum:biologics:il6|IL-6 inhibitors]] (tocilizumab, sarilumab)  * [[rheum:biologics:il17|IL-17 inhibitors]] (secukinumab, ixekizumab)  * [[rheum:biologics:il12_23|IL-12/23 inhibitors]] (ustekinumab)  * [[rheum:biologics:bcell|B-cell depletion]] (rituximab)  * [[rheum:biologics:tcell|T-cell co-stimulation]] (abatacept)  * [[rheum:biologics:complement|Complement inhibitors]] (eculizumab)==== Targeted Small Molecules ====  * [[rheum:jak:start|JAK inhibitors]] (tofacitinib, baricitinib, upadacitinib)  * [[rheum:smallmolecules:pde4|PDE4 inhibitors]] (apremilast)  * [[rheum:smallmolecules:other|Other targeted agents]]==== Calcineurin / mTOR ====  * [[rheum:calcineurin:tacrolimus|Tacrolimus]]  * [[rheum:calcineurin:cyclosporine|Cyclosporine]]  * [[rheum:mtor:sirolimus|Sirolimus / Everolimus]]==== Glucocorticoids ====  * [[rheum:glucocorticoids:start|Systemic steroids]]  * [[rheum:glucocorticoids:local|Local / intra-articular]]----===== Disease-Specific Pathways =====  * [[rheum:ra:start|Rheumatoid Arthritis (RA)]]  * [[rheum:psa:start|Psoriatic Arthritis (PsA)]]  * [[rheum:as:start|Ankylosing Spondylitis / AxSpA]]  * [[rheum:sle:start|Systemic Lupus Erythematosus (SLE)]]  * [[rheum:vasculitis:start|Vasculitides]]  * [[rheum:myositis:start|Inflammatory Myopathies]]  * [[rheum:giant_cell:start|Giant Cell Arteritis]]  * [[rheum:sjogren:start|Sjogren Syndrome]]  * [[rheum:ibd:start|IBD-associated arthritis]]----===== Monitoring & Safety =====  * [[rheum:monitoring:start|Baseline & ongoing monitoring]]  * [[rheum:infection_risk:start|Infection risk & vaccines]]  * [[rheum:pregnancy:start|Pregnancy & lactation considerations]]  * [[rheum:screening:start|TB / Hep B screening]]  * [[rheum:malignancy:start|Malignancy risk]]  * [[rheum:drug_interactions:start|Drug interactions]]----===== Pearls & Tables =====  * [[rheum:pearls:start|Clinical pearls]]  * [[rheum:tables:start|Mechanism -> adverse effect tables]]  * [[rheum:comparisons:start|Head-to-head comparisons]]