====== Immunosuppressants ======**Organized by mechanism, target, and clinical use**  <WRAP center round box 85%>This section covers **systemic immunosuppressive therapies** across specialties(rheumatology, transplant, dermatology, GI, nephrology, neurology).</WRAP>----===== Core Classes ========= Conventional / Antimetabolites ====  * [[immunosuppressants:antimetabolites:methotrexate|Methotrexate]]  * [[immunosuppressants:antimetabolites:azathioprine|Azathioprine]]  * [[immunosuppressants:antimetabolites:mycophenolate|Mycophenolate]]  * [[immunosuppressants:antimetabolites:leflunomide|Leflunomide]]==== Calcineurin / mTOR ====  * [[immunosuppressants:calcineurin:tacrolimus|Tacrolimus]]  * [[immunosuppressants:calcineurin:cyclosporine|Cyclosporine]]  * [[immunosuppressants:mtor:sirolimus|Sirolimus / Everolimus]]==== Biologic Agents ====  * [[immunosuppressants:biologics:tnf|TNF inhibitors]]  * [[immunosuppressants:biologics:il6|IL‑6 inhibitors]]  * [[immunosuppressants:biologics:il17|IL‑17 inhibitors]]  * [[immunosuppressants:biologics:il12_23|IL‑12/23 inhibitors]]  * [[immunosuppressants:biologics:bcell|B‑cell depletion]]  * [[immunosuppressants:biologics:tcell|T‑cell co‑stimulation]]  * [[immunosuppressants:biologics:complement|Complement inhibitors]]==== Targeted Small Molecules ====  * [[immunosuppressants:jak:start|JAK inhibitors]]  * [[immunosuppressants:pde4|PDE4 inhibitors]]  * [[immunosuppressants:s1p|S1P receptor modulators]]==== Glucocorticoids ====  * [[immunosuppressants:glucocorticoids:start|Systemic steroids]]----===== Cross‑Cutting Topics =====  * [[immunosuppressants:monitoring:start|Monitoring & lab surveillance]]  * [[immunosuppressants:infection_risk:start|Infection risk & vaccines]]  * [[immunosuppressants:screening:start|TB / Hep B screening]]  * [[immunosuppressants:pregnancy:start|Pregnancy & lactation]]  * [[immunosuppressants:drug_interactions:start|Drug interactions]]  * [[immunosuppressants:malignancy:start|Malignancy risk]]----===== Disease / Indication Index =====  * [[immunosuppressants:transplant:start|Transplant immunosuppression]]  * [[immunosuppressants:ibd:start|Inflammatory Bowel Disease]]  * [[immunosuppressants:derm:start|Dermatologic indications]]  * [[immunosuppressants:neuro:start|Neuro‑immunology]]  * [[immunosuppressants:renal:start|Nephrology / GN]]