====== Hydrocortisone ======

===== Classification =====
  * Short-acting systemic glucocorticoid
  * Also available topical and rectal

Parent class:
  * [[endocrine:drug_classes:corticosteroids|Corticosteroids]]

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===== Mechanism of Action =====
Binds intracellular glucocorticoid receptor → alters gene transcription → broad anti-inflammatory effects.

Has moderate mineralocorticoid activity.

See:
  * [[endocrine:physiology:glucocorticoid_signaling|Glucocorticoid Signaling]]

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===== Clinical Uses =====

Systemic:
  * [[endocrine:clinical:adrenal_insufficiency|Adrenal Insufficiency]]
  * Adrenal crisis
  * Severe inflammation

Topical:
  * [[dermatology:clinical:atopic_dermatitis|Dermatitis]]

Rectal:
  * [[gastroenterology:clinical:ibd|Ulcerative proctitis]]

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===== Clinical Pearls =====

  * Closest synthetic analog to cortisol.
  * Preferred for adrenal replacement therapy.
  * Has sodium-retaining effects.