====== Clobetasol ======

===== Classification =====
  * Very high-potency topical glucocorticoid (Class I)

Parent class:
  * [[endocrine:drug_classes:corticosteroids|Corticosteroids]]

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===== Mechanism of Action =====

Topical glucocorticoid receptor activation → decreased local cytokine production → reduced inflammation and immune cell activity.

See:
  * [[endocrine:physiology:glucocorticoid_signaling|Glucocorticoid Signaling]]

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===== Formulations =====

  * Cream
  * Ointment
  * Foam
  * Solution
  * Shampoo (psoriasis)

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===== Clinical Uses =====

  * Severe psoriasis
  * Refractory eczema
  * Lichen planus
  * Other severe inflammatory dermatoses

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===== Adverse Effects =====

Local:
  * Skin thinning
  * Striae
  * Telangiectasia
  * Hypopigmentation

Systemic (rare, with large-area use):
  * HPA axis suppression

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===== Clinical Pearls =====

  * Class I potency (strongest topical class).
  * Avoid long-term use.
  * Avoid use on face or intertriginous areas.
  * Limit duration (typically ≤2 weeks continuous use).