Differences

This shows you the differences between two versions of the page.

--- respiratory:start [2026/02/15 14:19] – andrew2393cns
+++ respiratory:start [2026/02/15 14:33] (current) – [How to Think About Dyspnea] andrew2393cns
@@ Line 1: / Line 1: @@
 ====== Respiratory Pharmacology ======
-{{tag>pharmacology respiratory}}
+==== Respiratory diseases fall into two fundamentally different categories: ====
-Respiratory pharmacology is divided by **WHAT is diseased**:
 <WRAP center round important 70%>
-AIRFLOW PROBLEM → treat the airway (bronchodilators & inhaled steroids)
+  * AIRWAY PROBLEM → obstruction & bronchospasm → bronchodilators + inhaled anti-inflammatories
+  *
-SCARRING PROBLEM → treat the lung tissue (antifibrotics & immunosuppression)
+  * PARENCHYMAL PROBLEM → alveolar injury & fibrosis → antifibrotics & immunosuppression
 </WRAP>
@@ Line 16: / Line 14: @@
 <WRAP half column>
-===== Airway Disease (Obstructive) =====
+===== Obstructive Physiology =====
+=== Airway Disease ===
 <WRAP info>
-Reversible airflow limitation → bronchodilation + anti-inflammation
+  * Problem: Air Cannot Get OUT Of The Lung
+  * Usually Reversible
 </WRAP>
-==== Core Conditions ====
+==== Core Disorders ====
   * [[respiratory:asthma|Asthma]]
   * [[respiratory:copd|COPD]]
@@ Line 30: / Line 30: @@
 ==== Bronchodilators ====
-  * [[respiratory:beta2_agonists|β2-Agonists (SABA / LABA)]]
+  * [[respiratory:beta2_agonists|β2-Agonists (SABA/LABA)]]
-  * [[respiratory:antimuscarinics|Antimuscarinics (SAMA / LAMA)]]
+  * [[respiratory:antimuscarinics|Antimuscarinics (SAMA/LAMA)]]
   * [[respiratory:methylxanthines|Methylxanthines]]
 ----
-==== Controllers ====
+==== Controllers (Reduce Inflammation) ====
   * [[respiratory:inhaled_corticosteroids|Inhaled Corticosteroids]]
   * [[respiratory:leukotriene_modifiers|Leukotriene Modifiers]]
@@ Line 43: / Line 43: @@
 ----
-==== Severe Asthma (Biologics) ====
+==== Severe Asthma Biologics ====
   * [[respiratory:biologics|Biologics Master Page]]
   * [[respiratory:biologics:anti_ige|Anti-IgE]]
@@ Line 52: / Line 52: @@
 ----
-==== Symptom Therapy ====
+==== Symptom Relief ====
-  * [[respiratory:antitussives_expectorants|Cough & Mucus Drugs]]
+  * [[respiratory:antitussives_expectorants|Cough & Mucus Therapy]]
   * [[respiratory:allergic_rhinitis|Allergic Rhinitis]]
   * [[respiratory:smoking_cessation|Smoking Cessation]]
@@ Line 61: / Line 61: @@
 <WRAP half column>
-===== Parenchymal Disease (Restrictive) =====
+===== Restrictive Physiology =====
+=== Parenchymal Disease ===
 <WRAP info>
-Irreversible tissue injury → fibrosis or immune-mediated inflammation
+  * Problem: Lung Tissue Cannot Expand
+  * Usually Progressive
 </WRAP>
@@ Line 89: / Line 91: @@
 ----
+==== Key Clinical Distinction ====
 <WRAP center round tip 90%>
-Bronchodilators treat obstruction
+  * Wheezing → bronchodilators
-Antifibrotics slow scarring
+  * Velcro crackles → antifibrotics
-They do NOT overlap.
+They treat completely different diseases.
 </WRAP>
@@ Line 103: / Line 106: @@
 ===== High-Yield Comparison =====
-^ Feature ^ Obstructive Disease ^ Restrictive Disease ^
+<WRAP center round box 50%>
+^ Feature ^ Airway Disease ^ Parenchymal Disease ^
+| Physiology | Obstructive | Restrictive |
 | Primary issue | Narrow airways | Scarred alveoli |
 | Reversibility | Often reversible | Progressive |
 | Main therapy | Bronchodilators ± ICS | Antifibrotics / Immunosuppression |
 | Clinical goal | Improve airflow | Slow decline |
+</WRAP>
 ----
-<WRAP info>
+===== How to Think About Dyspnea =====
-This page is organized by disease physiology to match clinical reasoning and board exam logic.
+<WRAP center round box 80%>
+  * Wheeze → Airway Drugs
+  * Crackles → Fibrosis Drugs
+  * Hypoxia Out Of Proportion → ILD Workup
 </WRAP>
+----