User Tools

Site Tools

Trace:
respiratory:start

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
respiratory:start [2026/02/15 14:18] – andrew2393cnsrespiratory:start [2026/02/15 14:33] (current) – [How to Think About Dyspnea] andrew2393cns
Line 1: Line 1:
 ====== Respiratory Pharmacology ====== ====== Respiratory Pharmacology ======
  
-{{tag>pharmacology respiratory}}+==== Respiratory diseases fall into two fundamentally different categories: ====
  
-Respiratory drugs treat disease through two fundamentally different mechanisms: +<WRAP center round important 70%> 
- +  * AIRWAY PROBLEM → obstruction & bronchospasm → bronchodilators + inhaled anti-inflammatories 
-<WRAP center round important 60%> +  *  
-**Airway Disease → bronchoconstriction + inflammation → bronchodilators & inhaled steroids** +  * PARENCHYMAL PROBLEM → alveolar injury & fibrosis → antifibrotics & immunosuppression
- +
-**Parenchymal Disease → tissue injury + fibrosis → antifibrotics & immunosuppression**+
 </WRAP> </WRAP>
  
Line 16: Line 14:
 <WRAP half column> <WRAP half column>
  
-===== AIRWAY DISEASE =====+===== Obstructive Physiology ===== 
 +=== Airway Disease ===
 <WRAP info> <WRAP info>
-Obstructive physiology → REVERSIBLE airflow limitation+  * Problem: Air Cannot Get OUT Of The Lung 
 +  * Usually Reversible
 </WRAP> </WRAP>
  
-==== Core Diseases ====+==== Core Disorders ====
   * [[respiratory:asthma|Asthma]]   * [[respiratory:asthma|Asthma]]
   * [[respiratory:copd|COPD]]   * [[respiratory:copd|COPD]]
-  * [[respiratory:asthma_copd_step_therapy|Step Therapy Quick Guide]] 
   * [[respiratory:exacerbations|Acute Exacerbations]]   * [[respiratory:exacerbations|Acute Exacerbations]]
 +  * [[respiratory:asthma_copd_step_therapy|Step Therapy Quick Guide]]
  
 ---- ----
Line 32: Line 32:
   * [[respiratory:beta2_agonists|β2-Agonists (SABA/LABA)]]   * [[respiratory:beta2_agonists|β2-Agonists (SABA/LABA)]]
   * [[respiratory:antimuscarinics|Antimuscarinics (SAMA/LAMA)]]   * [[respiratory:antimuscarinics|Antimuscarinics (SAMA/LAMA)]]
-  * [[respiratory:methylxanthines|Methylxanthines (Theophylline)]]+  * [[respiratory:methylxanthines|Methylxanthines]]
  
 ---- ----
  
-==== Anti-Inflammatory Controllers ==== +==== Controllers (Reduce Inflammation) ==== 
-  * [[respiratory:inhaled_corticosteroids|Inhaled Corticosteroids (ICS)]]+  * [[respiratory:inhaled_corticosteroids|Inhaled Corticosteroids]]
   * [[respiratory:leukotriene_modifiers|Leukotriene Modifiers]]   * [[respiratory:leukotriene_modifiers|Leukotriene Modifiers]]
-  * [[respiratory:mast_cell_stabilizers|Cromolyn]]+  * [[respiratory:mast_cell_stabilizers|Mast Cell Stabilizers]]
  
 ---- ----
Line 45: Line 45:
 ==== Severe Asthma Biologics ==== ==== Severe Asthma Biologics ====
   * [[respiratory:biologics|Biologics Master Page]]   * [[respiratory:biologics|Biologics Master Page]]
-  * [[respiratory:biologics:anti_ige|Omalizumab]] +  * [[respiratory:biologics:anti_ige|Anti-IgE]] 
-  * [[respiratory:biologics:anti_il5|Mepolizumab / Reslizumab / Benralizumab]] +  * [[respiratory:biologics:anti_il5|Anti-IL-5 / IL-5R]] 
-  * [[respiratory:biologics:anti_il4_13|Dupilumab]] +  * [[respiratory:biologics:anti_il4_13|Anti-IL-4/13]] 
-  * [[respiratory:biologics:anti_tslp|Tezepelumab]]+  * [[respiratory:biologics:anti_tslp|Anti-TSLP]]
  
 ---- ----
  
-==== Symptom Control ==== +==== Symptom Relief ==== 
-  * [[respiratory:antitussives_expectorants|Cough & Mucus Drugs]]+  * [[respiratory:antitussives_expectorants|Cough & Mucus Therapy]]
   * [[respiratory:allergic_rhinitis|Allergic Rhinitis]]   * [[respiratory:allergic_rhinitis|Allergic Rhinitis]]
   * [[respiratory:smoking_cessation|Smoking Cessation]]   * [[respiratory:smoking_cessation|Smoking Cessation]]
Line 61: Line 61:
 <WRAP half column> <WRAP half column>
  
-===== PARENCHYMAL DISEASE =====+===== Restrictive Physiology ===== 
 +=== Parenchymal Disease ===
 <WRAP info> <WRAP info>
-Restrictive physiology → IRREVERSIBLE tissue damage / immune injury+  * Problem: Lung Tissue Cannot Expand   
 +  * Usually Progressive
 </WRAP> </WRAP>
  
Line 89: Line 91:
 ---- ----
  
-==== Key Concept ====+==== Key Clinical Distinction ====
 <WRAP center round tip 90%> <WRAP center round tip 90%>
-Bronchodilators DO NOT treat pulmonary fibrosis   +  * Wheezing → bronchodilators   
-Antifibrotics DO NOT open airways  +  * Velcro crackles → antifibrotics  
  
-Students mix these constantly — boards love this distinction.+They treat completely different diseases.
 </WRAP> </WRAP>
  
Line 104: Line 106:
 ===== High-Yield Comparison ===== ===== High-Yield Comparison =====
  
-^ Feature ^ Asthma/COPD ^ Pulmonary Fibrosis ^ +<WRAP center round box 50%> 
-| Primary problem | Airway narrowing | Alveolar scarring |+^ Feature ^ Airway Disease ^ Parenchymal Disease ^
 | Physiology | Obstructive | Restrictive | | Physiology | Obstructive | Restrictive |
-| Reversibility | Yes | No | +| Primary issue | Narrow airways | Scarred alveoli | 
-| Main drugs | Bronchodilators + ICS | Antifibrotics | +| Reversibility | Often reversible | Progressive | 
-| Goal of therapy | Improve airflow | Slow decline |+| Main therapy | Bronchodilators ± ICS | Antifibrotics / Immunosuppression | 
 +| Clinical goal | Improve airflow | Slow decline | 
 +</WRAP>
  
 ---- ----
  
-<WRAP info> +===== How to Think About Dyspnea ===== 
-This page is organized by **mechanism of disease**, not by drug class — mirroring clinical reasoning and board exam logic.+ 
 +<WRAP center round box 80%> 
 +  * Wheeze → Airway Drugs   
 +  * Crackles → Fibrosis Drugs   
 +  * Hypoxia Out Of Proportion → ILD Workup
 </WRAP> </WRAP>
 +
 +----
respiratory/start.1771165098.txt.gz · Last modified: by andrew2393cns