Differences

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--- office_hours:inflammation:start [2026/02/15 17:41] – andrew2393cns
+++ office_hours:inflammation:start [2026/02/15 17:52] (current) – [High-Yield Framework — How Immune Drugs Differ] andrew2393cns
@@ Line 25: / Line 25: @@
 <WRAP center round box 95%>
-If you understand the pathway, you stop memorizing drug lists.
+You will be a better clinician if you understand the pathways, not just memorize some drugs
 </WRAP>
@@ Line 52: / Line 52: @@
 <WRAP half column>
-==== Episode 2 — Arachidonic Acid Pathway (NSAIDs vs Leukotrienes) ====
+==== Episode 2 — Arachidonic Acid (NSAIDs vs Leukotrienes) ====
 <WRAP lecturevideo>
@@ Line 90: / Line 90: @@
 <WRAP half column>
-==== Episode 4 — Hypersensitivity vs Autoimmunity (Clinical Patterns) ====
+==== Episode 4 — Hypersensitivity vs Autoimmunity ====
 <WRAP lecturevideo>
@@ Line 108: / Line 108: @@
 ----
-===== High-Yield Framework =====
-<WRAP center 90%>
+===== High-Yield Framework — How Immune Drugs Differ =====
-^ Target Level ^ Examples ^ What It Usually Does ^
-| Mast cells / histamine | antihistamines, omalizumab (IgE) | helps allergy symptoms; not great for deep autoimmune disease |
+<WRAP center 95%>
-| Arachidonic acid (COX/LOX) | NSAIDs, aspirin, zileuton, montelukast | pain/fever/inflammation; leukotrienes = airway + allergy |
+^ Depth of Action ^ What The Drug Is Really Doing ^ Drug Classes ^ Typical Clinical Use ^
-| Gene transcription | corticosteroids | broad suppression; powerful but lots of systemic adverse effects |
+| Surface (symptom relief) | Blocks mediators already released | [[allergy:drug_classes:first_generation_h1|Antihistamines]], [[immunology:biologics:anti_ige|Omalizumab]] | Seasonal allergies, urticaria |
-| Cytokines / signaling | TNF inhibitors, IL inhibitors, JAK inhibitors | “upstream” control; high impact in autoimmune disease |
+| Local chemical inflammation | Blocks inflammatory chemicals (prostaglandins / leukotrienes) | [[eicosanoids:nsaids:start|NSAIDs]], [[cardio:antiplatelet:aspirin|Aspirin]], [[respiratory:drugs:zileuton|Zileuton]], [[respiratory:drugs:montelukast|Montelukast]] | Pain, fever, mild asthma |
+| Broad immune suppression | Turns off inflammatory gene production | [[endocrine:drug_classes:corticosteroids|Corticosteroids]] | Severe inflammation, flares |
+| Targeted immune modulation | Blocks specific immune communication pathways | [[immunology:biologics:anti_tnf_agents|TNF inhibitors]], [[immunology:biologics:start|IL inhibitors]], [[immunology:jak_inhibitors:start|JAK inhibitors]] | Autoimmune disease, severe asthma, IBD |
 </WRAP>
-----
+<WRAP center round tip 90%>
+The deeper the drug acts → the stronger the disease control → the greater the infection risk.
+</WRAP>
+----
 ===== Related =====