User Tools

Site Tools

Trace:
office_hours:inflammation:start

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
office_hours:inflammation:start [2026/02/15 17:40] – andrew2393cnsoffice_hours:inflammation:start [2026/02/15 17:52] (current) – [High-Yield Framework — How Immune Drugs Differ] andrew2393cns
Line 4: Line 4:
  
 This series is the **mechanistic backbone** for a huge portion of pharmacology: This series is the **mechanistic backbone** for a huge portion of pharmacology:
-NSAIDs, corticosteroids, antihistamines, asthma meds, biologics, rheum drugs, and more.+NSAIDs, Corticosteroids, Antihistamines, Asthma Meds, Biologics, Rheum Drugs, and more.
  
 <WRAP center round important 90%> <WRAP center round important 90%>
Line 25: Line 25:
  
 <WRAP center round box 95%> <WRAP center round box 95%>
-If you understand the pathway, you stop memorizing drug lists.+You will be a better clinician if you understand the pathways, not just memorize some drugs
 </WRAP> </WRAP>
  
Line 31: Line 31:
  
 ===== Episodes ===== ===== Episodes =====
- 
-> Keep each episode as its own page (easy to expand later).   
-> This landing page stays clean and scalable. 
  
 <WRAP group> <WRAP group>
Line 55: Line 52:
 <WRAP half column> <WRAP half column>
  
-==== Episode 2 — Arachidonic Acid Pathway (NSAIDs vs Leukotrienes) ====+==== Episode 2 — Arachidonic Acid (NSAIDs vs Leukotrienes) ====
  
 <WRAP lecturevideo> <WRAP lecturevideo>
Line 93: Line 90:
 <WRAP half column> <WRAP half column>
  
-==== Episode 4 — Hypersensitivity vs Autoimmunity (Clinical Patterns) ====+==== Episode 4 — Hypersensitivity vs Autoimmunity ====
  
 <WRAP lecturevideo> <WRAP lecturevideo>
Line 111: Line 108:
 ---- ----
  
-===== High-Yield Framework ===== 
  
-<WRAP center 90%> +===== High-Yield Framework — How Immune Drugs Differ ===== 
-^ Target Level ^ Examples ^ What It Usually Does ^ + 
-| Mast cells / histamine | antihistamines, omalizumab (IgE) | helps allergy symptoms; not great for deep autoimmune disease | +<WRAP center 95%> 
-| Arachidonic acid (COX/LOX) | NSAIDs, aspirin, zileuton, montelukast | pain/fever/inflammation; leukotrienes = airway + allergy | +^ Depth of Action ^ What The Drug Is Really Doing ^ Drug Classes ^ Typical Clinical Use ^ 
-| Gene transcription | corticosteroids | broad suppression; powerful but lots of systemic adverse effects | +| Surface (symptom relief) | Blocks mediators already released | [[allergy:drug_classes:first_generation_h1|Antihistamines]], [[immunology:biologics:anti_ige|Omalizumab]] | Seasonal allergies, urticaria | 
-| Cytokines / signaling | TNF inhibitors, IL inhibitors, JAK inhibitors | “upstream” control; high impact in autoimmune disease |+| Local chemical inflammation | Blocks inflammatory chemicals (prostaglandins / leukotrienes) | [[eicosanoids:nsaids:start|NSAIDs]], [[cardio:antiplatelet:aspirin|Aspirin]], [[respiratory:drugs:zileuton|Zileuton]], [[respiratory:drugs:montelukast|Montelukast]] | Pain, fever, mild asthma | 
 +| Broad immune suppression | Turns off inflammatory gene production | [[endocrine:drug_classes:corticosteroids|Corticosteroids]] | Severe inflammation, flares | 
 +| Targeted immune modulation | Blocks specific immune communication pathways | [[immunology:biologics:anti_tnf_agents|TNF inhibitors]], [[immunology:biologics:start|IL inhibitors]], [[immunology:jak_inhibitors:start|JAK inhibitors]] | Autoimmune disease, severe asthma, IBD |
 </WRAP> </WRAP>
  
----- +<WRAP center round tip 90%> 
- +The deeper the drug acts → the stronger the disease control → the greater the infection risk. 
-===== Best Order ===== +</WRAP>
- +
-  - Episode 1 (Map) → Episode 2 (AA pathway) → Episode 3 (Cytokines) → Episode 4 (Patterns)+
  
 ---- ----
- 
 ===== Related ===== ===== Related =====
  
office_hours/inflammation/start.1771177203.txt.gz · Last modified: by andrew2393cns