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--- office_hours:inflammation:start [2026/02/15 17:39] – created andrew2393cns
+++ office_hours:inflammation:start [2026/02/15 17:52] (current) – [High-Yield Framework — How Immune Drugs Differ] andrew2393cns
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 {{ :office_hours:series:inflammation.png?600 |}}
+====== Understanding Inflammation (Office Hours Series) ======
+This series is the **mechanistic backbone** for a huge portion of pharmacology:
+NSAIDs, Corticosteroids, Antihistamines, Asthma Meds, Biologics, Rheum Drugs, and more.
+<WRAP center round important 90%>
+**Quick Links** \\
+  * [[office_hours:series:start|← Back to Office Hours: Series]]
+  * [[allergy:start|Allergy / Hypersensitivity]]
+  * [[eicosanoids:start|NSAIDs & Leukotrienes]]
+  * [[rheum:start|Rheumatology / Immunosuppressants]]
+  * [[oncology:start|Oncology (Immunotherapy / Supportive)]]
+</WRAP>
+----
+===== What You’ll Learn =====
+  * Acute vs chronic inflammation (what changes, and why it matters)
+  * Where **histamine, prostaglandins, leukotrienes, cytokines** fit
+  * How steroids differ from NSAIDs (and why biologics are “upstream”)
+  * How to predict **therapeutic benefit + adverse effects** from pathway position
+<WRAP center round box 95%>
+You will be a better clinician if you understand the pathways, not just memorize some drugs
+</WRAP>
+----
+===== Episodes =====
+<WRAP group>
+<WRAP half column>
+==== Episode 1 — The Inflammation Map (Big Picture) ====
+<WRAP lecturevideo>
+{{youtube>VIDEO_ID_HERE}}
+</WRAP>
+<WRAP center round important 60%>
+📄 **Download Slides (PDF)** \\
+{{:office_hours:inflammation:inflammation_map.pdf|Download Slides (PDF)}}
+</WRAP>
+→ [[office_hours:inflammation:episode_1|Open Episode 1 Page]]
+</WRAP>
+<WRAP half column>
+==== Episode 2 — Arachidonic Acid (NSAIDs vs Leukotrienes) ====
+<WRAP lecturevideo>
+{{youtube>VIDEO_ID_HERE}}
+</WRAP>
+<WRAP center round important 60%>
+📄 **Download Slides (PDF)** \\
+{{:office_hours:inflammation:arachidonic_acid_pathway.pdf|Download Slides (PDF)}}
+</WRAP>
+→ [[office_hours:inflammation:episode_2|Open Episode 2 Page]]
+</WRAP>
+</WRAP>
+----
+<WRAP group>
+<WRAP half column>
+==== Episode 3 — Cytokines & JAK/STAT (Why Biologics Work) ====
+<WRAP lecturevideo>
+{{youtube>VIDEO_ID_HERE}}
+</WRAP>
+<WRAP center round important 60%>
+📄 **Download Slides (PDF)** \\
+{{:office_hours:inflammation:cytokines_and_jak_stat.pdf|Download Slides (PDF)}}
+</WRAP>
+→ [[office_hours:inflammation:episode_3|Open Episode 3 Page]]
+</WRAP>
+<WRAP half column>
+==== Episode 4 — Hypersensitivity vs Autoimmunity ====
+<WRAP lecturevideo>
+{{youtube>VIDEO_ID_HERE}}
+</WRAP>
+<WRAP center round important 60%>
+📄 **Download Slides (PDF)** \\
+{{:office_hours:inflammation:hypersensitivity_vs_autoimmunity.pdf|Download Slides (PDF)}}
+</WRAP>
+→ [[office_hours:inflammation:episode_4|Open Episode 4 Page]]
+</WRAP>
+</WRAP>
+----
+===== High-Yield Framework — How Immune Drugs Differ =====
+<WRAP center 95%>
+^ Depth of Action ^ What The Drug Is Really Doing ^ Drug Classes ^ Typical Clinical Use ^
+| Surface (symptom relief) | Blocks mediators already released | [[allergy:drug_classes:first_generation_h1|Antihistamines]], [[immunology:biologics:anti_ige|Omalizumab]] | Seasonal allergies, urticaria |
+| Local chemical inflammation | Blocks inflammatory chemicals (prostaglandins / leukotrienes) | [[eicosanoids:nsaids:start|NSAIDs]], [[cardio:antiplatelet:aspirin|Aspirin]], [[respiratory:drugs:zileuton|Zileuton]], [[respiratory:drugs:montelukast|Montelukast]] | Pain, fever, mild asthma |
+| Broad immune suppression | Turns off inflammatory gene production | [[endocrine:drug_classes:corticosteroids|Corticosteroids]] | Severe inflammation, flares |
+| Targeted immune modulation | Blocks specific immune communication pathways | [[immunology:biologics:anti_tnf_agents|TNF inhibitors]], [[immunology:biologics:start|IL inhibitors]], [[immunology:jak_inhibitors:start|JAK inhibitors]] | Autoimmune disease, severe asthma, IBD |
+</WRAP>
+<WRAP center round tip 90%>
+The deeper the drug acts → the stronger the disease control → the greater the infection risk.
+</WRAP>
+----
+===== Related =====
+  * [[office_hours:series:start|Office Hours: Series]]
+  * [[office_hours:start|Office Hours Home]]
+  * [[lectures:start|Full Lecture Series]]
+  * [[start|PharmAtlas Home]]