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--- endocrine:insulin:start [2026/02/13 00:45] – created andrew2393cns
+++ endocrine:insulin:start [2026/02/13 00:52] (current) – [Insulin Comparison Table] andrew2393cns
@@ Line 46: / Line 46: @@
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+===== Insulin Comparison Table =====
+^ Type ^ Agent ^ Onset ^ Peak ^ Duration ^ Dosing Role ^ Key Features ^
+| Rapid-Acting | [[endocrine:insulin:lispro|Lispro]] | 10–15 min | ~1 hr | 3–5 hr | Mealtime | Rapid absorption, less stacking |
+| Rapid-Acting | [[endocrine:insulin:aspart|Aspart]] | 10–20 min | 1–3 hr | 3–5 hr | Mealtime | Structurally modified, rapid profile |
+| Rapid-Acting | [[endocrine:insulin:glulisine|Glulisine]] | 10–20 min | ~1 hr | 3–5 hr | Mealtime | Rapid analog, comparable to lispro/aspart |
+| Short-Acting | [[endocrine:insulin:regular|Regular]] | 30–60 min | 2–4 hr | 6–8 hr | Mealtime / IV use | Only insulin used IV (DKA, HHS) |
+| Intermediate | [[endocrine:insulin:nph|NPH]] | 1–2 hr | 4–8 hr | 12–18 hr | Basal (older regimens) | Protamine-bound, clear peak |
+| Long-Acting | [[endocrine:insulin:glargine|Glargine]] | 1–2 hr | Minimal | ~24 hr | Basal | pH-dependent precipitation |
+| Long-Acting | [[endocrine:insulin:detemir|Detemir]] | 1–2 hr | Minimal | 12–24 hr | Basal | Albumin binding, may require BID |
+| Ultra-Long | [[endocrine:insulin:degludec|Degludec]] | ~1 hr | None | >42 hr | Basal | Multi-hexamer depot, very stable |
+----
 ===== Types of Insulin =====
 Insulins are categorized by onset and duration.
 ==== Rapid-Acting (Mealtime) ====