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endocrine:drug_classes:corticosteroids [2026/02/12 20:01] – andrew2393cnsendocrine:drug_classes:corticosteroids [2026/02/12 20:18] (current) – [Topical Dermatologic Glucocorticoids] andrew2393cns
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 They are divided into: They are divided into:
- +  * Glucocorticoids (anti-inflammatory / immunosuppressive) 
-  * Glucocorticoids (anti-inflammatory, immunosuppressive) +  * Mineralocorticoids (volume regulation)
-  * Mineralocorticoids (volume and sodium regulation)+
  
 Core physiology: Core physiology:
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   * [[endocrine:physiology:glucocorticoid_signaling|Glucocorticoid Signaling Pathway]]   * [[endocrine:physiology:glucocorticoid_signaling|Glucocorticoid Signaling Pathway]]
  
-This is the master overview page. Each drug links to its full monograph.+★ = High-yield / core drug for mastery
  
 ---- ----
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 ===== Systemic Glucocorticoids ===== ===== Systemic Glucocorticoids =====
  
-^ Drug ^ Relative GC Potency ^ Mineralocorticoid Activity ^ Duration ^ +^ Drug ^ Relative GC Potency ^ Mineralocorticoid Activity ^ Duration ^ ★ ^ 
-| [[endocrine:drugs:hydrocortisone|Hydrocortisone]] | Low | Moderate | Short | +| [[endocrine:drugs:hydrocortisone|Hydrocortisone]] | Low | Moderate | Short | ★ | 
-| [[endocrine:drugs:cortisone|Cortisone]] | Low | Moderate | Short | +| [[endocrine:drugs:cortisone|Cortisone]] | Low | Moderate | Short |  | 
-| [[endocrine:drugs:prednisone|Prednisone]] | Moderate | Low | Intermediate | +| [[endocrine:drugs:prednisone|Prednisone]] | Moderate | Low | Intermediate | ★ | 
-| [[endocrine:drugs:prednisolone|Prednisolone]] | Moderate | Low | Intermediate | +| [[endocrine:drugs:prednisolone|Prednisolone]] | Moderate | Low | Intermediate | ★ | 
-| [[endocrine:drugs:methylprednisolone|Methylprednisolone]] | Moderate–High | Minimal | Intermediate | +| [[endocrine:drugs:methylprednisolone|Methylprednisolone]] | Moderate–High | Minimal | Intermediate | ★ | 
-| [[endocrine:drugs:triamcinolone|Triamcinolone]] | Moderate–High | None | Intermediate | +| [[endocrine:drugs:triamcinolone|Triamcinolone]] | Moderate–High | None | Intermediate |  | 
-| [[endocrine:drugs:dexamethasone|Dexamethasone]] | High | None | Long | +| [[endocrine:drugs:dexamethasone|Dexamethasone]] | High | None | Long | ★ | 
-| [[endocrine:drugs:betamethasone|Betamethasone]] | High | None | Long | +| [[endocrine:drugs:betamethasone|Betamethasone]] | High | None | Long | ★ |
- +
-Clinical use examples: +
-  * [[respiratory:clinical:asthma|Asthma]] +
-  * [[rheumatology:clinical:rheumatoid_arthritis|Rheumatoid Arthritis]] +
-  * [[gastroenterology:clinical:ibd|Inflammatory Bowel Disease]] +
-  * [[allergy:clinical:anaphylaxis|Anaphylaxis]] (adjunct)+
  
 ---- ----
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 ===== Inhaled Glucocorticoids ===== ===== Inhaled Glucocorticoids =====
  
-Primarily used in:+^ Drug ^ Notes ^ ★ ^ 
 +| [[endocrine:drugs:beclomethasone|Beclomethasone]] | Early ICS |  | 
 +| [[endocrine:drugs:budesonide|Budesonide]] | Also GI-targeted form | ★ | 
 +| [[endocrine:drugs:ciclesonide|Ciclesonide]] | Prodrug activated in lung |  | 
 +| [[endocrine:drugs:flunisolide|Flunisolide]] | Less common |  | 
 +| [[endocrine:drugs:fluticasone|Fluticasone]] | Most commonly used | ★ | 
 +| [[endocrine:drugs:mometasone|Mometasone]] | Long pulmonary retention |  | 
 + 
 +Used in:
   * [[respiratory:clinical:asthma|Asthma]]   * [[respiratory:clinical:asthma|Asthma]]
- 
-^ Drug ^ Relative Potency ^ Notes ^ 
-| [[endocrine:drugs:beclomethasone|Beclomethasone]] | Moderate | Early ICS agent | 
-| [[endocrine:drugs:budesonide|Budesonide]] | Moderate | Also GI-targeted form | 
-| [[endocrine:drugs:ciclesonide|Ciclesonide]] | Moderate | Prodrug, activated in lung | 
-| [[endocrine:drugs:flunisolide|Flunisolide]] | Moderate | Less commonly used | 
-| [[endocrine:drugs:fluticasone|Fluticasone]] | High | Common ICS | 
-| [[endocrine:drugs:mometasone|Mometasone]] | High | Long pulmonary retention | 
  
 ---- ----
  
 ===== Intranasal Glucocorticoids ===== ===== Intranasal Glucocorticoids =====
 +
 +^ Drug ^ Notes ^ ★ ^
 +| [[endocrine:drugs:beclomethasone|Beclomethasone]] | Also inhaled |  |
 +| [[endocrine:drugs:budesonide|Budesonide]] | Also inhaled | ★ |
 +| [[endocrine:drugs:flunisolide|Flunisolide]] | Less common |  |
 +| [[endocrine:drugs:fluticasone|Fluticasone]] | First-line congestion therapy | ★ |
 +| [[endocrine:drugs:mometasone|Mometasone]] | High potency |  |
 +| [[endocrine:drugs:triamcinolone|Triamcinolone]] | OTC option |  |
  
 Used in: Used in:
   * [[allergy:clinical:allergic_rhinitis|Allergic Rhinitis]]   * [[allergy:clinical:allergic_rhinitis|Allergic Rhinitis]]
- 
-^ Drug ^ Notes ^ 
-| [[endocrine:drugs:beclomethasone|Beclomethasone]] | Also inhaled | 
-| [[endocrine:drugs:budesonide|Budesonide]] | Also inhaled | 
-| [[endocrine:drugs:flunisolide|Flunisolide]] | Less common | 
-| [[endocrine:drugs:fluticasone|Fluticasone]] | Most commonly used | 
-| [[endocrine:drugs:mometasone|Mometasone]] | High potency | 
-| [[endocrine:drugs:triamcinolone|Triamcinolone]] | Available OTC | 
  
 ---- ----
  
 ===== Topical Dermatologic Glucocorticoids ===== ===== Topical Dermatologic Glucocorticoids =====
 +
 +^ Drug ^ Typical Potency ^ ★ ^
 +| [[endocrine:drugs:hydrocortisone|Hydrocortisone]] | Low | ★ |
 +| [[endocrine:drugs:desonide|Desonide]] | Low–Moderate |  |
 +| [[endocrine:drugs:triamcinolone|Triamcinolone]] | Moderate | ★ |
 +| [[endocrine:drugs:betamethasone|Betamethasone]] | High | ★ |
 +| [[endocrine:drugs:fluocinonide|Fluocinonide]] | High |  |
 +| [[endocrine:drugs:clobetasol|Clobetasol]] | Very High | ★ |
  
 Used in: Used in:
   * [[dermatology:clinical:atopic_dermatitis|Atopic Dermatitis]]   * [[dermatology:clinical:atopic_dermatitis|Atopic Dermatitis]]
   * [[dermatology:clinical:contact_dermatitis|Contact Dermatitis]]   * [[dermatology:clinical:contact_dermatitis|Contact Dermatitis]]
- 
-^ Drug ^ Typical Potency Range ^ 
-| [[endocrine:drugs:hydrocortisone|Hydrocortisone]] | Low | 
-| [[endocrine:drugs:desonide|Desonide]] | Low–Moderate | 
-| [[endocrine:drugs:triamcinolone|Triamcinolone]] | Moderate | 
-| [[endocrine:drugs:betamethasone|Betamethasone]] | High | 
-| [[endocrine:drugs:fluocinonide|Fluocinonide]] | High | 
-| [[endocrine:drugs:clobetasol|Clobetasol]] | Very High | 
- 
-(Topical potency classes I–VII should be detailed on a separate potency page.) 
  
 ---- ----
  
 ===== GI-Targeted Glucocorticoids ===== ===== GI-Targeted Glucocorticoids =====
 +
 +^ Drug ^ Notes ^ ★ ^
 +| [[endocrine:drugs:budesonide|Budesonide]] | High first-pass metabolism | ★ |
 +| [[endocrine:drugs:hydrocortisone|Hydrocortisone]] | Rectal formulations |  |
  
 Used in: Used in:
   * [[gastroenterology:clinical:ibd|Inflammatory Bowel Disease]]   * [[gastroenterology:clinical:ibd|Inflammatory Bowel Disease]]
- 
-^ Drug ^ Notes ^ 
-| [[endocrine:drugs:budesonide|Budesonide]] | High first-pass metabolism; targeted GI effect | 
-| [[endocrine:drugs:hydrocortisone|Hydrocortisone]] | Rectal formulations | 
  
 ---- ----
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 ===== Mineralocorticoids ===== ===== Mineralocorticoids =====
  
-Primarily aldosterone-like effects (volume expansion). +^ Drug ^ Primary Use ^ ★ ^ 
- +| [[endocrine:drugs:fludrocortisone|Fludrocortisone]] | Adrenal insufficiency | ★ |
-^ Drug ^ Primary Use ^ +
-| [[endocrine:drugs:fludrocortisone|Fludrocortisone]] | [[endocrine:clinical:adrenal_insufficiency|Adrenal Insufficiency]] |+
  
 ---- ----
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 ===== High-Yield Pearls ===== ===== High-Yield Pearls =====
  
-  * All systemic glucocorticoids suppress the HPA axis with prolonged use. +  * Dexamethasone and betamethasone have no mineralocorticoid activity.
-  * Dexamethasone and betamethasone have **no mineralocorticoid activity**.+
   * Inhaled steroids are foundational therapy in asthma.   * Inhaled steroids are foundational therapy in asthma.
   * Intranasal steroids are first-line for allergic rhinitis congestion.   * Intranasal steroids are first-line for allergic rhinitis congestion.
-  * One molecule = one page; routes are described within drug monographs.+  * Chronic systemic use suppresses ACTH. 
 +  * One molecule = one page; routes described within drug monographs.
endocrine/drug_classes/corticosteroids.1770926513.txt.gz · Last modified: by andrew2393cns