autonomics:antimuscarinics
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| autonomics:antimuscarinics [2026/02/15 15:23] – [Antimuscarinics (Muscarinic Antagonists)] andrew2393cns | autonomics:antimuscarinics [2026/02/15 15:29] (current) – [Antimuscarinics / AntiCholinergics (Muscarinic Antagonists)] andrew2393cns | ||
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| - | ====== Antimuscarinics (Muscarinic Antagonists) ====== | + | ====== Antimuscarinics |
| Antimuscarinics block acetylcholine at muscarinic receptors and therefore inhibit parasympathetic activity. | Antimuscarinics block acetylcholine at muscarinic receptors and therefore inhibit parasympathetic activity. | ||
| Line 6: | Line 6: | ||
| <WRAP center round important 70%> | <WRAP center round important 70%> | ||
| - | Antimuscarinics = "Turn OFF rest-and-digest" | + | Antimuscarinics = "Turn OFF rest-and-digest" |
| </ | </ | ||
| Line 27: | Line 27: | ||
| <WRAP center round box 85%> | <WRAP center round box 85%> | ||
| - | Dry as a bone → ↓ secretions | + | * Dry as a bone → ↓ secretions |
| - | Blind as a bat → mydriasis + cycloplegia | + | |
| - | Hot as a hare → ↓ sweating | + | |
| - | Red as a beet → vasodilation | + | |
| - | Mad as a hatter → delirium | + | |
| </ | </ | ||
| Line 48: | Line 48: | ||
| ---- | ---- | ||
| - | ===== Drug Groups | + | ===== Major Clinical Uses ===== |
| - | ==== Respiratory (Inhaled) | + | ==== Bronchodilation |
| * [[respiratory: | * [[respiratory: | ||
| * [[respiratory: | * [[respiratory: | ||
| + | * [[respiratory: | ||
| + | * [[respiratory: | ||
| + | * [[respiratory: | ||
| + | * [[respiratory: | ||
| - | ==== Bladder | + | ==== Overactive |
| - | * Oxybutynin | + | * [[gu: |
| - | * Tolterodine | + | * [[gu: |
| - | * Solifenacin | + | * [[gu: |
| + | * [[gu: | ||
| + | * [[gu: | ||
| - | ==== Ophthalmic | + | ==== GI Antispasmodic |
| - | * Atropine | + | * [[gi: |
| - | * Tropicamide | + | * [[gi: |
| - | ==== GI Antispasmodics | + | ==== Motion Sickness / CNS ==== |
| - | * Dicyclomine | + | * [[cns: |
| - | * Hyoscyamine | + | * [[cns: |
| - | ==== CNS ==== | + | ==== Ophthalmic Mydriasis |
| - | * Benztropine | + | * [[ophthalmology: |
| - | * Scopolamine | + | * [[ophthalmology: |
| + | * [[ophthalmology: | ||
| ---- | ---- | ||
| Line 75: | Line 82: | ||
| ===== Adverse Effects ===== | ===== Adverse Effects ===== | ||
| - | All antimuscarinics share the same predictable toxicity: | + | All antimuscarinics share predictable toxicity: |
| * Dry mouth | * Dry mouth | ||
| Line 97: | Line 104: | ||
| <WRAP round tip 90%> | <WRAP round tip 90%> | ||
| - | If a symptom involves excessive secretion or smooth muscle contraction → antimuscarinic drugs treat it. | + | If a symptom involves excessive secretion or smooth muscle contraction → antimuscarinics |
| </ | </ | ||
| + | Common real-world uses: | ||
| * COPD bronchodilation | * COPD bronchodilation | ||
| * Overactive bladder | * Overactive bladder | ||
| Line 110: | Line 118: | ||
| * [[respiratory: | * [[respiratory: | ||
| - | * GI antispasmodics | ||
| - | * Bladder antimuscarinics | ||
autonomics/antimuscarinics.1771169002.txt.gz · Last modified: by andrew2393cns